期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 19, 期 1, 页码 61-68出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2007.01.006
关键词
glucose metabolism; human body composition; lipid lipoprotein profile; obesity; premenopausal women
This study assessed the effects of combined chromium picolinate (CP) and conjugated linoleic acid (CLA) supplementation on energy restriction and exercise-induced changes in body composition, glucose metabolism, lipid lipoprotein profile and blood pressure in overweight, premenopausal women. For 12 weeks, 35 women [age 36 +/- 1 years (mean +/- S.E.M.); BMI 28.0 +/- 0.5 kg/m(2)] were counseled to consume a 2092 kJ/day (500 kcal/day) energy deficit diet and performed 30 min of moderate-intensity walking or jogging 5 days/week. The women were randomly assigned to ingest either CP-CLA [400 mu g chromium (Cr), 1.8 g CLA in 2.4 g tonalin oil, n = 19] or placebo (< 0.1 mu g Cr, 2.4 g canola oil, n = 16). Compared to baseline, urinary Cr excretion increased 22-fold, plasma CLA isomer 18:2 (c9,t11) content increased 79% and plasma CLA isomer 18:2 (t10,c12) became detectable in CP-CLA and were unchanged in Placebo. Over time, body weight decreased 3.5 +/- 0.5% (CP-CLA -2.6 +/- 0.5; placebo -2.5 +/- 0.5 kg) and fat mass decreased 8.9 +/- 1.3% (CP-CLA -2.7 +/- 0.5, placebo -2.4 +/- 0.5 kg), with no differences in responses between groups. Fasting blood hemoglobin A(1c), plasma glucose and insulin, a homeostatic assessment of insulin resistance, serum total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol, triacylglycerol (TG), CHOL/HDL ratio, TG/HDL ratio and sitting systolic and diastolic blood pressures were not changed over time or influenced by CP-CLA. The use of a combined CP and CLA supplement for 3 months does not affect diet- and exercise-induced changes in weight and body composition or improve indexes of metabolic and cardiovascular health in young overweight women. (c) 2008 Elsevier Inc. All rights reserved.
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