期刊
JOURNAL OF NUTRITION HEALTH & AGING
卷 17, 期 6, 页码 578-584出版社
SPRINGER FRANCE
DOI: 10.1007/s12603-013-0047-2
关键词
homocysteine; physical functioning; muscle; aging
资金
- Ministry of Health, Welfare, and Sports of the Netherlands
The current study aimed to examine homocysteine in relation to different aspects of physical functioning. Cross-sectional and longitudinal data (3-years follow-up) from the Longitudinal Aging Study Amsterdam (LASA) were used. The study was performed in persons aged a parts per thousand yen 65 years (N= 1301 after imputation). Different measures of physical functioning, including muscle mass, grip strength, functional limitations, and falling were regarded as outcomes. Gender and serum creatinine level were investigated as effect modifiers. Results were stratified by gender. In men, higher homocysteine levels were associated with lower grip strength (Quartile 4: regression coefficient (B)= -3.07 (-4.91; -1.22)), and more functional limitations at baseline (Quartile 4: B= 1.15 (0.16-2.14)). In women, higher homocysteine levels were associated with more functional limitations after 3 years (Quartile 4: B= 1.19 (0.25; 2.13)). Higher homocysteine levels were not associated with low muscle mass or falling. These data suggest an inverse association of homocysteine levels with functional limitations in older men and women, and with muscle strength in older men.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据