期刊
JOURNAL OF NUTRITION
卷 143, 期 9, 页码 1445-1450出版社
ELSEVIER SCIENCE INC
DOI: 10.3945/jn.113.177121
关键词
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资金
- Italian Ministry of Health
- United States National Institute on Aging
- Spanish Ministry of Science and Innovation [AGL2009-13906-C02-01]
- Mapfre Foundation
- University of Barcelona
- Barcelona Knowledge Campus
- Campus of International Excellence program of the Spanish Ministry of Education, Culture and Sport
- MICINN
- European Social Funds
- Spanish postdoctoral programme Fondo de Investigacion Sanitaria [CD09/00133]
Polyphenols might have a role in the prevention of several chronic diseases, but evaluating total dietary polyphenol (TDP) intake from self-reported questionnaires is inaccurate and unreliable. A promising alternative is to use total urinary polyphenol (TUP) concentration as a proxy measure of intake. The current study evaluated the relationship between TUPs and TDPs and all-cause mortality during a 12-y period among older adult participants. The study population included 807 men and women aged 65 y and older from the Invecchiare in Chianti study, a population-based cohort study of older adults living in the Chianti region of Tuscany, Italy. TUP concentrations were measured at enrolment (1998-2000) using the Folin-Ciocalteau assay after a solid-phase extraction. TDPs were also estimated at baseline throughout a validated food frequency questionnaire and using our database based on USDA and Phenol-Explorer databases. We modeled associations using Kaplan-Meier survival and Cox proportional hazards models, with adjustment for potential confounders. During the 12-y follow-up, 274 participants (34%) died. At enrollment, TUP excretion adjusted for age and sex tended to be greater in participants who survived 1163 +/- 62 mg gallic acid equivalents (GAE)/d)I than in those who died (143 +/- 63 mg GAE/d) (P = 0.07). However, no significant differences were observed for TDPs. In the multivariable Cox model, participants in the highest tertile of TUP at enrolment had a lower mortality rate than those in the lowest tertile [HR = 0.70 (95% Cl: 0.49-0.99); P-trend = 0.045], whereas no significant associations were found between TDP and overall mortality. TUP is an independent risk factor for mortality among community-dwelling older adults, suggesting that high dietary intake of polyphenols may be associated with longevity.
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