期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 17, 期 7, 页码 5172-5186出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cp04969a
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资金
- Board of Research in Nuclear sciences (BRNS), Mumbai, India
- Council of Scientific and Industrial Research (CSIR), New Delhi, India
- council of scientific and industrial Research (CSIR), New Delhi
In this study, an attempt has been made to understand the interaction between collagen like peptides (CPs) with a gold nanosurface (AuNS) using a classical molecular dynamics simulation. Results reveal that the adsorption of CPs onto the gold surface depends on the amino acid composition of the collagen like peptides. It is evident from the findings that the Hyp residue of collagen interacts favorably with the AuNS. It is interesting to note that the model CP without a Hyp residue does not adsorb well on the surface. Results indicate that gold nanosurfaces or gold nanoparticles can be exploited to detect breast cancer due to the increased content of Hyp residues in the Gly-X-AA-Y-AA triplet of collagen in breast cancer tissues. These results provide useful information for designing collagen based scaffolds for tissues engineering applications.
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