期刊
JOURNAL OF NUCLEAR MEDICINE
卷 55, 期 12, 页码 1959-1965出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.114.143347
关键词
F-18-FDG PET; HMPAO SPECT; sensitivity; specificity; diagnosis; Alzheimer's disease; dementia with Lewy bodies
资金
- National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme [PB-PG-1207-13105]
- NIHR Newcastle Biomedical Research Centre and Lewybody Dementia Biomedical Research Unit based at Newcastle upon Tyne Hospitals NHS Foundation Trust
- Newcastle University
- NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia based at Cambridge University Hospitals NHS Foundation Trust
- National Institute for Health Research
- University of Cambridge
- Lilly/Avid Radiopharmaceuticals
- GE Healthcare
- Cytox
- Elan
- Lilly
- National Institutes of Health Research (NIHR) [PB-PG-1207-13105] Funding Source: National Institutes of Health Research (NIHR)
- National Institute for Health Research [PB-PG-1207-13105] Funding Source: researchfish
Brain imaging with glucose (F-18-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority of one method have not been undertaken. Methods: Subjects with Alzheimer disease (AD; n = 38) and dementia with Lewy bodies (DLB; n = 30) and controls (n = 30) underwent F-18-FDG PET and SPECT in balanced order. The main outcome measure was area under the curve (AUC) of receiver-operating-characteristic analysis of visual scan rating. Results: Consensus diagnosis with F-18-FDG PET was superior to SPECT for both dementia vs. no-dementia (AUC = 0.93 vs. 0.72, P = 0.001) and AD vs. DLB (AUC = 0.80 vs. 0.58, P = 0.005) comparisons. The sensitivity and specificity for dementia/no-dementia was 85% and 90%, respectively, for F-18-FDG PET and 71% and 70%, respectively, for SPECT. Conclusion: (F-18-FDG) PET was significantly superior to blood flow SPECT. We recommend F-18-FDG PET be performed instead of perfusion SPECT for the differential diagnosis of degenerative dementia if functional imaging is indicated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据