期刊
JOURNAL OF NUCLEAR MEDICINE
卷 55, 期 10, 页码 1567-1572出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.114.141705
关键词
PET/MR imaging; PET/MRI; C-13-magnetic resonance; prostate; prostate cancer; hyperpolarized C-13; metabolism
资金
- National Institutes of Health [R01 CA166766, P41 EB013598]
Hyperpolarization using dissolution dynamic nuclear polarization has emerged as a versatile method to dramatically improve the MR signal of low-sensitivity nuclei. This technique facilitates the study of real-time metabolism in vitro and in vivo using C-13-enriched substrates and has been applied to numerous models of human disease. In particular, several mechanisms underlying prostate cancer have been interrogated using hyperpolarized C-13 MR spectroscopy. This review highlights key metabolic shifts seen in prostate cancer, their study by hyperpolarized C-13 MR spectroscopy, and the development of new platforms for metabolic study.
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