期刊
JOURNAL OF NUCLEAR MEDICINE
卷 54, 期 1, 页码 83-89出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.112.111476
关键词
SPECT (single-photon emission computed tomography); quantification; scatter correction; attenuation correction; validation
资金
- Australian Research Council
- NSW Cancer Council
- Cure Cancer Australia Foundation
SPECT has traditionally been regarded as nonquantitative. Advances in multimodality gamma-cameras (SPECT/CT), algorithms for image reconstruction, and sophisticated compensation techniques to correct for photon attenuation and scattering have, however, now made quantitative SPECT viable in a manner similar to quantitative PET (i.e., kBq.cm(-3), standardized uptake value). This review examines the evidence for quantitative SPECT and demonstrates clinical studies in which the accuracy of the reconstructed SPECT data has been assessed in vivo. SPECT reconstructions using CT-based compensation corrections readily achieve accuracy for Tc-99m to within +/- 10% of the known concentration of the radiotracer in vivo. Quantification with other radionuclides is also being introduced. SPECT continues to suffer from poorer photon detection efficiency (sensitivity) and spatial resolution than PET; however, it has the benefit in some situations of longer radionuclide half-lives, which may better suit the biologic process under examination, as well as the ability to perform multitracer studies using pulse height spectroscopy to separate different radiolabels.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据