期刊
JOURNAL OF NUCLEAR MEDICINE
卷 54, 期 4, 页码 571-577出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.112.112219
关键词
myocardial blood flow quantification; myocardial perfusion imaging; rubidium positron emission tomography; coronary flow reserve; myocardial perfusion reserve
资金
- Imaging in Cardiovascular Therapeutics grant from the Ontario Research Fund [RE02038]
- Molecular Function and Imaging Program grant from the Ontario Heart and Stroke Foundation [PRG6242]
Routine quantification of myocardial blood flow (MBF) requires robust and reproducible processing of dynamic image series. The goal of this study was to evaluate the reproducibility of 3 highly automated software programs commonly used for absolute MBF and flow reserve (stress/rest MBF) assessment with Rb-82 PET imaging. Methods: Dynamic rest and stress Rb-82 PET scans were selected in 30 sequential patient studies performed at 3 separate institutions using 3 different 3-dimensional PET/CT scanners. All 90 scans were processed with 3 different MBF quantification programs, using the same 1-tissue-compartment model. Global (left ventricle) and regional (left anterior descending, left circumflex, and right coronary arteries) MBF and flow reserve were compared among programs using correlation and Bland-Altman analyses. Results: All scans were processed successfully by the 3 programs, with minimal operator interactions. Global and regional correlations of MBF and flow reserve all had an R-2 of at least 0.92. There was no significant difference in flow values at rest (P = 0.68), stress (P = 0.14), or reserve (P = 0.35) among the 3 programs. Bland-Altman coefficients of reproducibility (1.96 x SD) averaged 0.26 for MBF and 0.29 for flow reserve differences among programs. Average pairwise differences were all less than 10%, indicating good reproducibility for MBF quantification. Global and regional SD from the line of perfect agreement averaged 0.15 and 0.17 mL/min/g, respectively, for MBF, compared with 0.22 and 0.26, respectively, for flow reserve. Conclusion: The 1-tissue-compartment model of Rb-82 tracer kinetics is a reproducible method for quantification of MBF and flow reserve with 3-dimensional PET/CT imaging.
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