期刊
JOURNAL OF NUCLEAR MEDICINE
卷 54, 期 9, 页码 1584-1587出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.112.117275
关键词
F-18-FDG; MR imaging; fMRI; cold-activation; brown adipose tissue
资金
- NIH [DK087317, DK055545, DK033201, DK081604, DK046200, RR025757, P30 DK036836]
- Clinical Translational Science Award from the National Center for Research Resources (NCRR), Harvard Catalyst [UL1RR025758]
- BIDMC from the National Center for Research Resources (NCRR), Harvard Catalyst
- Harvard Clinical and Translational Science Center (NIH) [UL1 RR 025758]
- Harvard University
- Eli Lilly Foundation
The aim of this study was to assess the volume and function of human brown adipose tissue (BAT) in vivo using MR imaging. Methods: BAT volumes under thermoneutral conditions in the cervical areas were assessed via water-fat contrast using the Dixon method and via water-saturation efficiency using fast spin-echo and T2-weighted images. The existence of cervical BAT was also assessed by F-18-FDG PET/CT scans in the same subjects. BAT functionality was assessed via functional MR imaging (fMRI) blood oxygenation level-dependent (BOLD) signal changes in response to a mild cold challenge. Results: Under thermoneutral conditions, we were able to distinguish BAT from white adipose tissue in the cervical and supraclavicular fat. BAT showed higher water-to-fat contrast and higher water-saturation efficiency in MR imaging scans. The location and volume of BAT assessed by MR imaging were comparable to the measurements by F-18-FDG PET/CT scans. During mild cold challenge, BOLD fMRI signal increased in BAT by 10.7% +/- 1.8% (P < 0.01). Conclusion: We demonstrated the feasibility of using MR imaging and fMRI to assess BAT volume and BAT responses to mild cold stimulation in the cervical areas of human subjects.
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