期刊
JOURNAL OF NUCLEAR MEDICINE
卷 51, 期 -, 页码 107S-121S出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.109.068221
关键词
MRI; PET; SPECT; myocardial infarction; noninvasive imaging; remodeling
资金
- [AHA 0855409E]
- [R01 HL078650]
- [R01 HL065662]
- [R01 HL093038]
- [K08 HL079984]
- [R01 HL058582]
Advances in cardiovascular molecular imaging have come at a rapid pace over the last several years. Multiple approaches have been taken to better understand the structural, molecular, and cellular events that underlie the progression from myocardial injury to myocardial infarction (MI) and, ultimately, to congestive heart failure. Multimodality molecular imaging including SPECT, PET, cardiac MRI, and optical approaches is offering new insights into the pathophysiology of MI and left ventricular remodeling in small-animal models. Targets that are being probed include, among others, angiotensin receptors, matrix metalloproteinases, integrins, apoptosis, macrophages, and sympathetic innervation. It is only a matter of time before these advances are applied in the clinical setting to improve post-MI prognostication and identify appropriate therapies in patients to prevent the onset of congestive heart failure.
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