期刊
JOURNAL OF NUCLEAR MEDICINE
卷 50, 期 7, 页码 1013-1016出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.109.064055
关键词
molecular imaging; oncology; PET/CT; cell therapy; reporter gene
资金
- NCI NIH HHS [P50 CA086438, P30 CA008748, R01 CA102352] Funding Source: Medline
A promising role of cellular therapies in cancer treatment is reflected by the constantly growing number of clinical trials with adoptively transferred cells. Direct and indirect cell labeling for the nuclear imaging of transferred cells has been proven reliable for imaging adoptive cellular therapies. Both methods show their advantages and limitations. Direct labeling is a relatively easy, inexpensive, and well-established methodology. Indirect labeling using a reporter gene imaging paradigm allows for reliable, stable, and harmless visualization of cellular trafficking, persistence, proliferation, and function at the target site. It is expected that new human-derived reporter genes will be rapidly translated into clinical applications that require repetitive imaging for the effective monitoring of various genetic and cellular therapies.
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