期刊
JOURNAL OF NUCLEAR MEDICINE
卷 49, 期 -, 页码 43S-63S出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.107.045930
关键词
glucose metabolism; amino acid metabolism; lipid metabolism; PET; optical imaging; MRI
Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.
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