期刊
JOURNAL OF NUCLEAR MEDICINE
卷 49, 期 11, 页码 1735-1738出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.108.053041
关键词
PET/CT; peptide-based probes; SPELT/CT; cholecystokinin/gastrin; somatostatin analogs
Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent the molecular basis for in vivo imaging with radiolabeled peptide probes. Somatostatin-derived tracers, designed to image the sst(2)-overexpressing neuroendocrine tumors, have enjoyed almost 2 decades of successful development and extensive clinical applications. More recent developments include second- and third-generation somatostatin analogs, with a broader receptor subtype profile or with antagonistic properties. Emerging tracers for other peptide receptors, including cholecystokinin/gastrin and GLP-1 analogs for neuroendocrine tumors, bombesin and neuropeptide-Y analogs for prostate or breast cancers, or Arg-Gly-Asp peptides for neoangiogenesis labeling, are also in current development. Application fields include both SPECT/CT and PET/CT.
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