期刊
JOURNAL OF NUCLEAR CARDIOLOGY
卷 21, 期 2, 页码 251-267出版社
SPRINGER
DOI: 10.1007/s12350-013-9845-5
关键词
Aneurysm; aorta; molecular imaging; inflammation; remodeling
资金
- National Institutes of Health [R01HL112992, R01HL114703]
- Department of Veterans Affairs Merit Award [I0BX001750]
Imaging cellular and molecular processes associated with aneurysm expansion, dissection, and rupture can potentially transform the management of patients with thoracic and abdominal aortic aneurysm. Here, we review recent advances in molecular imaging of aortic aneurysm, focusing on imaging modalities with the greatest potential for clinical translation and application, PET, SPECT, and MRI. Inflammation (e.g., with F-18-FDG, nanoparticles) and matrix remodeling (e.g., with matrix metalloproteinase-targeted tracers) are highlighted as promising targets for molecular imaging of aneurysm. Potential alternative or complementary approaches to molecular imaging for aneurysm risk stratification are briefly discussed.
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