期刊
JOURNAL OF NUCLEAR CARDIOLOGY
卷 16, 期 6, 页码 878-887出版社
SPRINGER
DOI: 10.1007/s12350-009-9118-5
关键词
Myocardial perfusion scintigraphy; intima media thickness; peripheral arterial disease; type 2 diabetes mellitus
资金
- Danish Cardiovascular Research Academy (DaCRA)
- Danish Diabetes Association
- Danish Heart Foundation
- Overlaegeradet of Odense University Hospital
- Institute of Clinical Research
- University of Southern Denmark
- Sehested Hansen's Foundation
- Family Hede Nielsen's Foundation
- Bernhard and wife Marie Klein's Grant
Cardiovascular disease (CVD) is the leading cause of death in type 2 diabetes mellitus (T2DM) patients. We examined the relationship between CVD in different vascular territories. T2DM patients without known or suspected CVD (n = 305) referred consecutively to a diabetes clinic for the first time and age-matched nondiabetic reference subjects (n = 40) were screened for myocardial ischemia, carotid, and peripheral arterial disease by means of myocardial perfusion scintigraphy, carotid artery ultrasonography, and peripheral ankle and toe systolic blood pressure measurements. In the T2DM patients, the prevalence of myocardial ischemia, carotid, and peripheral arterial disease was 30%, 42%, and 15%, respectively, almost three times higher than in the reference subjects (P = 0.007, P = 0.001, and P = 0.09, respectively). T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease had a significantly increased risk of CVD in other vascular territories as well (OR: 1.99, 2.09, and 3.09, respectively). However, 40%, 52%, and 22% of the T2DM patients with myocardial ischemia, carotid, or peripheral arterial disease demonstrated exclusively this particular type of CVD manifestation. In T2DM patients, signs of CVD in one vascular territory carry a significantly increased risk of CVD in other territories, although many patients only presented one manifestation.
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