期刊
JOURNAL OF NON-CRYSTALLINE SOLIDS
卷 357, 期 2, 页码 664-670出版社
ELSEVIER
DOI: 10.1016/j.jnoncrysol.2010.06.075
关键词
Mean square displacement; Dynamical transition; Lysozyme; Trehalose; Sucrose; Resolution function; Elastic incoherent neutron scattering
The main aim of the present work is to investigate the dynamical effects of the addition of disaccharides to hydrated lysozyme. The Self-Distribution-Function procedure is at first applied on Elastic Incoherent Neutron Scattering data obtained by the IN13 spectrometer on trehalose/H2O and sucrose/H2O where it highlights a different Q-dependence for the two disaccharides. Then a quantitative analysis of the Mean Square Displacement of lysozyme/trehalose/H2O and of lysozyme/sucrose/H2O from Elastic Incoherent Neutron Scattering data obtained by the IN10 spectrometer is presented. It is shown how the resolution function gives rise to a time integration of a given time-dependent Mean Square Displacement function. Furthermore the analysis shows that the protein dynamical transition, registered at a temperature value of about T = 200-220 K in the H2O hydrated lysozyme sample, is inhibited by the addition of the disaccharides. (C) 2010 Elsevier B.V. All rights reserved.
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