期刊
JOURNAL OF NEUROVIROLOGY
卷 15, 期 3, 页码 275-281出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/13550280902913271
关键词
DTI; HIV dementia; MMP-1; MMP-7; neuroAIDS; segmentation
资金
- National Institutes of Health [MH66705, MH080636, NS052580, MH075673, NS044807, NS049465]
- NATIONAL INSTITUTE OF MENTAL HEALTH [K23MH066705, R01MH080636, P30MH075673] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R21NS052580, R01NS044807] Funding Source: NIH RePORTER
Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity. Journal of NeuroVirology (2009) 15, 275-281.
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