期刊
JOURNAL OF NEUROVIROLOGY
卷 15, 期 1, 页码 81-89出版社
SPRINGER
DOI: 10.1080/13550280802380563
关键词
CNS autoimmune demyelinating diseases; multiple sclerosis; intestinal mucosa; mucins; N-acetylneuraminic acid; virus receptors
资金
- NIH [R01NS034497]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034497, R21NS059724] Funding Source: NIH RePORTER
DA and GDVII are strains of Theiler's murine encephalomyelitis virus (TMEV). DA virus mutant DApB encodes VP2 puff B of GDVII, whereas DApBL2M contains VP1 loop II of GDVII with a point mutation in VP2 puff B. Neuraminidase treatment of cells inhibited infection by DA and DApB, but not GDVII or DApBL2M viruses; sialic acid (SA) binding correlated with virus persistence. In virus binding assays to intestine sections, all four TMEVs bound goblet cells and the mucus of the epithelium that was SA dependent. Therefore, differences in SA composition on different cell types can affect tropism and infection.
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