期刊
JOURNAL OF NEUROVIROLOGY
卷 14, 期 6, 页码 563-568出版社
SPRINGER
DOI: 10.1080/13550280802290606
关键词
adeno-associated virus; baculovirus; gene therapy; hybrid viral vector
资金
- Institute of Bioengineering and Nanotechnology
- Agency for Science, Technology and Research (A*STAR), Singapore
To prolong the transient gene expression mediated by baculoviral vector, the inverted terminal repeats and Rep gene of adeno-associated virus were incorporated into the genome of baculovirus, creating a hybrid baculovirus-adeno-associated viral (AAV) vector. By using previously constructed composite neuron-specific and astrocyte-specific promoters in this hybrid viral vector, sustained transgene expressions could he achieved in human neuronal and glial cell lines, but not in the correspondent rodent cell lines. This hybrid baculovirus-AAV vector might be useful for gene therapy of chronic neurological diseases in the central nervous system, such as Parkinson's disease and Alzheimer's disease. Journal of NeuroVirology (2008) 14, 563 568.
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