期刊
JOURNAL OF NEUROTRAUMA
卷 31, 期 16, 页码 1375-1385出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2014.3385
关键词
neuroproteomic; synaptic dysfunction; synaptic junction proteins; traumatic brain injury
Extensive research and scientific efforts have been focused on the elucidation of the pathobiology of cellular and axonal damage following traumatic brain injury (TBI). Conversely, few studies have specifically addressed the issue of synaptic dysfunction. Synaptic junction proteins may be involved in post-TBI alterations, leading to synaptic loss or disrupted plasticity. A Synapse Protein Database on synapse ontology identified 109 domains implicated in synaptic activities and over 5000 proteins, but few of these demonstrated to play a role in the synaptic dysfunction after TBI. These proteins are involved in neuroplasticity and neuromodulation and, most importantly, may be used as novel neuronal markers of TBI for specific intervention.
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