期刊
JOURNAL OF NEUROTRAUMA
卷 30, 期 12, 页码 1023-1034出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2012.2729
关键词
EphA4; magnetic resonance imaging; neurotrauma; spinal cord injury
资金
- National Health and Medical Research Council [511212, APP1017308]
- Australian Research Council [DP110103201]
- Lisa Palmer bequest
- Spinal Cure Australia
Blocking the action of inhibitory molecules at sites of central nervous system injury has been proposed as a strategy to promote axonal regeneration and functional recovery. We have previously shown that genetic deletion or competitive antagonism of EphA4 receptor activity promotes axonal regeneration and functional recovery in a mouse model of lateral hemisection spinal cord injury. Here we have assessed the effect of blocking EphA4 activation using the competitive antagonist EphA4-Fc in a rat model of thoracic contusive spinal cord injury. Using a ledged tapered balance beam and open-field testing, we observed significant improvements in recovery of locomotor function after EphA4-Fc treatment. Consistent with functional improvement, using high-resolution ex vivo magnetic resonance imaging at 16.4T, we found that rats treated with EphA4-Fc had a significantly increased cross-sectional area of the dorsal funiculus caudal to the injury epicenter compared with controls. Our findings indicate that EphA4-Fc promotes functional recovery following contusive spinal cord injury and provides further support for the therapeutic benefit of treatment with the competitive antagonist in acute cases of spinal cord injury.
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