期刊
JOURNAL OF NEUROTRAUMA
卷 28, 期 1, 页码 113-125出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2010.1332
关键词
cerebrospinal fluid; finite element model; spinal cord injury
资金
- European Community [MEST-CT-2005-020599]
While recent studies have demonstrated the importance of the initial mechanical insult in the severity of spinal cord injury, there is a lack of information on the detailed cord-column interaction during such events. In vitro models have demonstrated the protective properties of the cerebrospinal fluid, but visualization of the impact is difficult. In this study a computational model was developed in order to clarify the role of the cerebrospinal fluid and provide a more detailed picture of the cord-column interaction. The study was validated against a parallel in vitro study on bovine tissue. Previous assumptions about complete subdural collapse before any cord deformation were found to be incorrect. Both the presence of the dura mater and the cerebrospinal fluid led to a reduction in the longitudinal strains within the cord. The division of the spinal cord into white and grey matter perturbed the bone fragment trajectory only marginally. In conclusion, the cerebrospinal fluid had a significant effect on the deformation pattern of the cord during impact and should be included in future models. The type of material models used for the spinal cord and the dura mater were found to be important to the stress and strain values within the components, but less important to the fragment trajectory.
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