期刊
JOURNAL OF NEUROTRAUMA
卷 38, 期 10, 页码 1441-1444出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2008.0536
关键词
dysautonomia; outcome; vegetative state
This study found that dysautonomia following brain injury can impact patient recovery and prognosis, with non-traumatic patients experiencing worse outcomes compared to traumatic patients, and non-traumatic patients with dysautonomia having the poorest prognosis.
A dramatic disorder tentatively attributed to diencephalic-hypothalamic damage or dysfunction, dysautonomia, affects recovery from brain injury. Its incidence, correlation with etiology, and relevance as a predictor of outcome were retrospectively surveyed in 333 patients in vegetative state (VS) for more than 2 weeks at admission. Outcome was assessed according to the Glasgow Outcome Scale. Data were treated statistically by multi-variate analyses. Dysautonomia occurred in 26.1% of patients, with greater incidence among post-traumatic (31.9%) than non-traumatic (15.8%) patients. Outcome was worse among non-traumatic than post-traumatic patients irrespective of dysautonomia, and worst among non-traumatic patients with dysautonomia. Dysautonomia proved common among patients in VS (with incidence depending on etiology and age) and influenced the patients' outcome through mechanisms still to be defined, but conceivably mediated by diencephalic-hypothalamic unbalance.
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