期刊
JOURNAL OF NEUROTRAUMA
卷 25, 期 6, 页码 593-602出版社
MARY ANN LIEBERT INC
DOI: 10.1089/neu.2007.0477
关键词
cortical contusion injury; edema; neuroprotection; progesterone; traumatic brain injury
资金
- NIA NIH HHS [AG 21981] Funding Source: Medline
Traumatic brain injury (TBI) results in an accumulation of edema and loss of brain tissue. Progesterone (PROG) has been reported to reduce edema and cortical tissue loss in a bilateral prefrontal cortex injury. This study tests the hypothesis that PROG is neuroprotective following a unilateral parietal cortical contusion injury (CCI). Adult male Sprague- Dawley rats were subjected to a moderate unilateral TBI using the CCI model. Rats were given 8 mg/kg PROG 15 min post- injury with four subsequent injections (6 h, and days 1, 2, and 3). Edema was determined 3 days post- injury, while cortical tissue sparing was also evaluated at 7 days post- injury. Animals were injured and given one of four treatments: (I) vehicle; (II) low dose: 8 mg/kg PROG; (III) high dose: 16 mg/kg PROG; (IV) tapered: 8 mg/kg PROG. Animals were given an initial injection within 15 min, followed by five injections (6 h, and days 1, 2, 3, and 4). Group IV received two additional injections (4 mg/kg on day 5; 2 mg/kg on day 6). PROG failed to alter both cortical edema and tissue sparing at any dose. Failure to modify two major sequelae associated with TBI brings into question the clinical usefulness of PROG as an effective treatment for all types of brain injury.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据