期刊
JOURNAL OF NEUROSURGERY-SPINE
卷 17, 期 5, 页码 438-448出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2012.7.SPINE12212
关键词
glioblastoma multiforme; spinal metastasis; metastasis; oncology
资金
- American Brain Tumor Association
- CNS Spine Fellowship
- AANS/CNS Spine Section Apfelbaum Award
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research UCLA Scholars in Translational Medicine Program Award
- Stein Oppenheimer Endowment Award
- Jason Dessel Memorial Seed Grant
Glioblastoma multiforme (GBM) is one of the most common and aggressive primary brain tumors, composing 12%-20% of all intracranial tumors in adults. Average life expectancy is merely 12-14 months following initial diagnosis. Patients with this neoplasm have one of the worst 5-year survival rates among all cancers despite aggressive multimodal treatment consisting of maximal tumor resection, radiation therapy, and adjuvant chemotherapy. With recent advancements in management strategies, there has been improvement in the overall trend in patient outcomes: however, recurrence remains nearly inevitable. While most tumors recur locally, metastases to distal locations have become more common. Specifically, the last decade has seen an increased incidence of spinal metastases, representing an emerging complication in patients with intracranial GBM. However, the literature regarding prevention strategies and the presentation of spinal metastases has remained scarce. As local control of primary lesions continues to improve, more cases of spinal metastases are likely to be seen. In this review the authors present a new case of metastatic GBM to the L-5 nerve root, and they summarize previous cases of intracranial GBM with leptomeningeal spinal metastatic disease. They also characterize key features of this disease presentation and discuss areas of future investigation necessary for enhanced prevention and treatment of this complication. (http://thejns.org/doi/abs/10.3171/2012.7.SPINE12212)
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