期刊
JOURNAL OF NEUROSURGERY-SPINE
卷 14, 期 5, 页码 561-569出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2010.12.SPINE10286
关键词
osteoporosis; vertebroplasty; vertebral compression fracture; spine; pain
资金
- Shiraz University of Medical Sciences
- Apadana Tajhizgostar Co.
Object. Osteoporotic vertebral compression fractures (VCFs) are a major cause of increased morbidity in older patients. This randomized controlled trial compared the efficacy of percutaneous vertebroplasty (PV) versus optimal medical therapy (OMT) in controlling pain and improving the quality of life (QOL) in patients with VCFs. Efficacy was measured as the incidence of new vertebral fractures after PV, restoration of vertebral body height (VBH), and correction of deformity. Methods. Of 105 patients with acute osteoporotic VCFs, 82 were eligible for participation: 40 patients underwent PV and 42 received OMT. Primary outcomes were control of pain and improvement in QOL before treatment, and these were measured at 1 week and at 2, 6, 12, 24, and 36 months after the beginning of the treatment. Radiological evaluation to measure VBH and sagittal index was performed before and after treatment in both groups and after 36 months of follow-up. Results. The authors found a statistically significant improvement in pain in the PV group compared with the OMT group at 1 week (difference -3.1,95% CI -3.72 to -2.28; p < 0.001). The QOL improved significantly in the PV group (difference -14, 95% CI -15 to -12.82; p < 0.028). One week after PV, the average VBH restoration was 8 mm and the correction of deformity was 8 degrees. The incidence of new fractures in the OMT group (13.3%) was higher than in the PV group (2.2%; p < 0.01). Conclusions. The PV group had statistically significant improvements in visual analog scale and QOL scores maintained over 24 months, improved VBH maintained over 36 months, and fewer adjacent-level fractures compared with the OMT group. (DOI: 10.3171/2010.12.SPINE10286)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据