期刊
JOURNAL OF NEUROSURGERY
卷 115, 期 6, 页码 1072-1077出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2011.6.JNS11129
关键词
allergy; cancer; epidemiology; family history; hormones; immune factors; meningioma; radiation; oncology
资金
- Brain Science Foundation
- Meningioma Mommas
- National Institutes of Health [CA109468, CA109461, CA109745, CA108473, CA109475]
Object. Little is known about the epidemiology of meningioma, the most frequently reported primary brain tumor in the US. The authors undertook a case-control study to examine the relationship between family and personal medical history and meningioma risk. Methods. The authors compared the personal and first-degree family histories of 1124 patients with meningioma (age range 20-79 years) in Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area, and 8 Houston counties between May I, 2006, and February 26, 2010, and the histories of 1000 control individuals who were frequency-matched for age, sex, and geography. Results. The patients were more likely than the controls to report a first-degree family history of meningioma (OR 4.4,95% CI 1.6-11.5), and there was an even stronger association in younger cases. The patients were less likely than controls to report immune conditions including allergy (OR 0.6, 95% CI 0.5-0.7) but were more likely to report a history of thyroid cancer (OR 4.7, 95% CI 1.02-21.5) or leukemia (OR 5.4, 95% CI 1.2-24.1) (most after radiotherapy). Among women. patients were more likely than controls to report hormonally related conditions-uterine fibroid tumors (OR 1.2,95% CI 1.0-1.5), endometriosis (OR 1.5, 95% CI 1.5-2.1), and breast cancer (OR 1.4,95% Cl 0.8-2.3). Conclusions. The influence of genetics, the immune system, and radiation near the head on meningioma risk is suggested in the authors' findings; the role of hormones is intriguing but requires further study. (DOI: 10.3171/2011.6.JNS11129)
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