期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 87, 期 3, 页码 599-608出版社
WILEY
DOI: 10.1002/jnr.21890
关键词
hypoxia-ischemia; minocycline; neonate; neuroinflammation; neuroprotection
Minocycline is a second-generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic-ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action. (C) 2008 Wiley-Liss, Inc.
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