期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 186, 期 2, 页码 165-170出版社
ELSEVIER
DOI: 10.1016/j.jneumeth.2009.11.013
关键词
Animal model; Behavior; Depression; Diurnal; Nocturnal; Arvicanthis niloticus
资金
- University of Minnesota
- UROP
- National Institute of Mental Health [MH53433]
Circadian rhythms are strongly implicated in affective disorders and some recent studies suggested that diurnal rodents might be advantageous model animals for them. In line with this possibility, previous work demonstrated that in the diurnal fat sand rat, short photoperiod conditions result in depression- and anxiety-like behavioral phenotype that is relieved with bright light treatment. To further explore the possibility of using diurnal species as model animals for affective disorders, the present study examined the effects of short photoperiod schedule in an additional diurnal rodent, the unstriped Nile grass rat. Results indicate that 6 weeks short photoperiod (5 h light/19 h dark) regimen induced depression-like behavior in the forced swim test and the saccharin preference test compared with animals maintained in a neutral photoperiod regimen (12 h light/12 h dark). No effects were shown in the light/dark box model of anxiety or in a test for spontaneous activity. These results demonstrate that photoperiod manipulations in diurnal rodents induce affective-like behavioral change and support the possibility that diurnal rodents might provide a good potential as model animals for depression spectrum disorders. (C) 2009 Elsevier B.V. All rights reserved.
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