期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 169, 期 1, 页码 141-157出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2007.12.010
关键词
impedance; electrode; LFP; phase; frequency
资金
- NEI NIH HHS [R01 EY008890, P30 EY008126, P30 EY008126-19, R01-EY08890, R01 EY008890-17, P301-EY08126] Funding Source: Medline
- NICHD NIH HHS [P30 HD015052-27, P30 HD015052, P30-HD015052] Funding Source: Medline
Interest in local field potentials (LFPs) and action potential shape has increased markedly. The present work describes distortions of these signals that occur for two reasons. First, the microelectrode recording circuit operates as a voltage divider producing frequency-dependent attenuation and phase shifts when electrode impedance is not negligible relative to amplifier input impedance. Because of the much higher electrode impedance at low frequencies, this occurred over frequency ranges of LFPs measured by neurophysiologists for one head-stage tested. Second, frequency-dependent phase shifts are induced by subsequent filters. Thus, we report these effects and the resulting amplitude envelope delays and distortion of waveforms recorded through a commercial data acquisition system and a range of tungsten microelectrodes. These distortions can be corrected, but must be accounted for when interpreting field potential and spike shape data. (c) 2007 Elsevier B.V. All rights reserved.
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