期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 36, 页码 7844-7851出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0760-18.2018
关键词
GABA; healthy aging; magnetic resonance spectroscopy; proactive inhibition; reactive inhibition
资金
- Research Foundation Flanders [G0708.14, G089818N]
- MEMODYN [30446199]
- KU Leuven Research Fund Grant [C16/15/070]
- National Institutes of Health (NIH) [R01-EB-016089, R01-023963, P41-EB015909]
- NIH [K99-MH-107719]
Healthy aging is accompanied by motor inhibition deficits that involve a slower process of stopping a prepotent motor response (i.e., reactive inhibition) rather than a diminished ability to anticipate stopping (i.e., proactive inhibition). Some studies suggest that efficient motor inhibition is related to GABAergic function. Since age-related alterations in the GABA system have also been reported, motor inhibition impairments might be linked to GABAergic alterations in the cortico-subcortical network that mediates motor inhibition. Thirty young human adults (mean age, 23.2 years; age range, 18-34 years; 14 men) and 29 older human adults (mean age, 67.5 years; age range, 60-74 years; 13 men) performed a stop-signal task with varying levels of stop-signal probability. GABA (+) levels were measured with magnetic resonance spectroscopy (MRS) in right inferior frontal cortex, pre-supplementary motor area (pre-SMA), left sensorimotor cortex, bilateral striatum, and occipital cortex. We found that reactive inhibition was worse in older adults compared with young adults, as indicated by longer stop-signal reaction times (SSRTs). No group differences in proactive inhibition were observed as both groups slowed down their response to a similar degree with increasing stop-signal probability. The MRS results showed that tissue-corrected GABA (+) levels were on average lower in older as compared with young adults. Moreover, older adults with lower GABA (+) levels in the pre-SMA were slower at stopping (i.e., had longer SSRTs). These findings suggest a role for the GABA system in reactive inhibition deficits.
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