期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 36, 页码 7787-7799出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2667-17.2018
关键词
feedback processing; motor control; motor variability; nonhuman primates; primary motor cortex; reaching
资金
- Canadian Institutes of Health Research (CIHR)
- Uehara Memorial Foundation
- CIHR fellowship
- GlaxoSmithKline Chair in Neuroscience
Many studies highlight that human movements are highly successful yet display a surprising amount of variability from trial to trial. There is a consistent pattern of variability throughout movement: initial motor errors are corrected by the end of movement, suggesting the presence of a powerful online control process. Here, we analyze the trial-by-trial variability of goal-directed reaching in nonhuman primates (five male Rhesus monkeys) and demonstrate that they display a similar pattern of variability during reaching, including a strong negative correlation between initial and late hand motion. We then demonstrate that trial-to-trial neural variability of primary motor cortex (M1) is positively correlated with variability of future hand motion (tau = similar to 160 ms) during reaching. Furthermore, the variability of M1 activity is also correlated with variability of past hand motion (tau = similar to 90 ms), but in the opposite polarity (i.e., negative correlation). Partial correlation analysis demonstrated that M1 activity independently reflects the variability of both past and future hand motions. These findings provide support for the hypothesis that M1 activity is involved in online feedback control of motor actions.
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