期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 6, 页码 2321-2330出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4547-13.2014
关键词
basket cells; disinhibition; eyeblink; forward model; inverse model; molecular layer interneurons
资金
- Searle Scholars Program
- National Institutes of Health [R01 MH093727]
- National Research Foundation of Singapore (Competitive Research Programme grant)
- World Class Institute Program of the National Research Foundation of Korea
- Ministry of Education, Science and Technology of Korea [WCI 2009-003]
Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking. We used an optogenetic approach in awake mice to show for the first time that transiently suppressing spontaneous activity in a population of PCs is sufficient to cause discrete movements that can be systematically modulated in size, speed, and timing depending on how much and how long PC firing is suppressed. We further demonstrate that this fine control of movement kinematics is mediated by a graded disinhibition of target neurons in the deep cerebellar nuclei. Our results prove a long-standing model of cerebellar function and provide the first demonstration that suppression of inhibitory signals can act as a powerful mechanism for the precise control of behavior.
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