期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 11, 页码 4022-4026出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5407-13.2014
关键词
brain stimulation; dorsolateral prefrontal cortex; executive functions; false memory; memory encoding; neuroenhancement
资金
- Werner Reichardt Centre for Integrative Neuroscience (CIN) at the Eberhard Karls University of Tubingen
- Deutsche Forschungsgemeinschaft (DFG) [EXC 307]
- University Hospital Tubingen [2086-1-0]
- German Research Council (Deutsche Forschungsgemeinschaft) [PL 525/1-1]
- CIN [PP 2011_11]
Human memory is dynamic and flexible but is also susceptible to distortions arising from adaptive as well as pathological processes. Both accurate and false memory formation require executive control that is critically mediated by the left prefrontal cortex (PFC). Transcranial direct current stimulation (tDCS) enables noninvasive modulation of cortical activity and associated behavior. The present study reports that tDCS applied to the left dorsolateral PFC (dlPFC) shaped accuracy of episodic memory via polaritiy-specific modulation of false recognition. When applied during encoding of pictures, anodal tDCS increased whereas cathodal stimulation reduced the number of false alarms to lure pictures in subsequent recognition memory testing. These data suggest that the enhancement of excitability in the dlPFC by anodal tDCS can be associated with blurred detail memory. In contrast, activity-reducing cathodal tDCS apparently acted as a noise filter inhibiting the development of imprecise memory traces and reducing the false memory rate. Consistently, the largest effect was found in the most active condition (i.e., for stimuli cued to be remembered). This first evidence for a polarity-specific, activity-dependent effect of tDCS on false memory opens new vistas for the understanding and potential treatment of disturbed memory control.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据