期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 2, 页码 629-645出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3859-13.2014
关键词
axon regeneration; MAP kinases; C. elegans; DLK; laser axotomy; neural regeneration
资金
- National Science Foundation
- McKnight Endowment Fund for Neuroscience
- Christopher and Dana Reeve Foundation
- Amerisure Charitable Foundation
- Howard Hughes Medical Institute
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0950955] Funding Source: National Science Foundation
Axons of the mammalian CNS lose the ability to regenerate soon after development due to both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for regeneration. The complex molecular events required for robust regeneration of mature neurons are not fully understood, particularly in vivo. To identify genes affecting axon regeneration in Caenorhabditis elegans, we performed both an RNAi-based screen for defective motor axon regeneration in unc-70/beta-spectrin mutants and a candidate gene screen. From these screens, we identified at least 50 conserved genes with growth-promoting or growth-inhibiting functions. Through our analysis of mutants, we shed new light on certain aspects of regeneration, including the role of beta-spectrin and membrane dynamics, the antagonistic activity of MAP kinase signaling pathways, and the role of stress in promoting axon regeneration. Many gene candidates had not previously been associated with axon regeneration and implicate new pathways of interest for therapeutic intervention.
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