期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 6, 页码 2231-2243出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1619-13.2014
关键词
cytokine; microglia; neurogenesis; neurosphere; oligodendrogenesis; subventricular zone
资金
- MEXT, Japan [KAKENHI 21700422]
- Program for Promotion of Fundamental Studies in Health Sciences of NIBIO, Japan
- Health and Labor Science Research Grant for Research on Risks of Chemicals
- Labor Science Research Grant for Research on New Drug Development from the MHLW, Japan
- Health and Labor Science Research Grant for Research on Publicly Essential Drugs and Medical Devices, Japan
Although microglia have long been considered as brain resident immune cells, increasing evidence suggests that they also have physiological roles in the development of the normal CNS. In this study, we found large numbers of activated microglia in the forebrain subventricular zone (SVZ) of the rat from P1 to P10. Pharmacological suppression of the activation, which produces a decrease in levels of a number of proinflammatory cytokines (i.e., IL-1 beta, IL-6, TNF-alpha, and IFN-gamma) significantly inhibited neurogenesis and oligodendrogenesis in the SVZ. In vitro neurosphere assays reproduced the enhancement of neurogenesis and oligodendrogenesis by activated microglia and showed that the cytokines revealed the effects complementarily. These results suggest that activated microglia accumulate in the early postnatal SVZ and that they enhance neurogenesis and oligodendrogenesis via released cytokines.
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