期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 49, 页码 16433-16441出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3141-14.2014
关键词
brain structure; motivation; prefrontal cortex; reward
资金
- Intramural Research Program of the National Institute of Neurological Disorders and Stroke
- National Institutes of Health
Interindividual differences in the effects of reward on performance are prevalent and poorly understood, with some individuals being more dependent than others on the rewarding outcomes of their actions. The origin of this variability in reward dependence is unknown. Here, we tested the relationship between reward dependence and brain structure in healthy humans. Subjects trained on a visuomotor skill-acquisition task and received performance feedback in the presence or absence of reward. Reward dependence was defined as the statistical trial-by-trial relation between reward and subsequent performance. We report a significant relationship between reward dependence and the lateral prefrontal cortex, where regional gray-matter volume predicted reward dependence but not feedback alone. Multivoxel pattern analysis confirmed the anatomical specificity of this relationship. These results identified a likely anatomical marker for the prospective influence of reward on performance, which may be of relevance in neurorehabilitative settings.
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