期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 46, 页码 15192-15199出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3233-14.2014
关键词
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资金
- Medical Research Council United Kingdom
- PRESTO, Japan Science and Technology Agency, Tokyo, Japan
- National Institutes of Health T32 Graduate Trainee on Systems and Molecular Neurobiology Sciences Training Grant
- National Institutes of Health [T32 MH064931, F31 NS082213]
- Velux Foundation
- Swiss National Science Foundation
- MRC [MC_U105170643] Funding Source: UKRI
- Medical Research Council [MC_U105170643] Funding Source: researchfish
The transcriptional architecture of intracellular circadian clocks is similar across phyla, but in mammals interneuronal mechanisms confer a higher level of circadian integration. The suprachiasmatic nucleus (SCN) is a unique model to study these mechanisms, as it operates as a similar to 24 h clock not only in the living animal, but also when isolated in culture. This clock in a dish can be used to address fundamental questions, such as how intraneuronal mechanisms are translated by SCN neurons into circuit-level emergent properties and how the circuit decodes, and responds to, light input. This review addresses recent developments in understanding the relationship between electrical activity, [Ca2+](i), and intracellular clocks. Furthermore, optogenetic and chemogenetic approaches to investigate the distinct roles of neurons and glial cells in circuit encoding of circadian time will be discussed, as well as the epigenetic and circuit-level mechanisms that enable the SCN to translate light input into coherent daily rhythms.
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