期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 21, 页码 7137-7147出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4386-13.2014
关键词
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资金
- SciEX-NMS
- Swiss National Science Foundation
- Foundation 450eme
- Fonds Jean Falk-Variant
- Hungarian Eotvos Scholarship
- Hungarian Scientific Research Fund [NF101773, T109754]
- Wellcome Trust
- National Office for Research and Technology (Neurogen)
- Swartz Foundation
- Marie Curie International Outgoing Fellowship within the European Union Seventh Framework Programme for Research and Technological Development
GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various network oscillations. To disentangle their roles in thalamocortical rhythms, we focally deleted synaptic, gamma 2 subunit-containing GABA-ARs in the thalamus using viral intervention in mice. After successful removal of gamma 2 subunit clusters, spontaneous and evoked GABAergic synaptic currents disappeared in thalamocortical cells when the presynaptic, reticular thalamic (nRT) neurons fired in tonic mode. However, when nRT cells fired in burst mode, slow phasic GABA-AR-mediated events persisted, indicating a dynamic, burst-specific recruitment of nonsynaptic GABA-ARs. In vivo, removal of synaptic GABA-ARs reduced the firing of individual thalamocortical cells but did not abolish slow oscillations or sleep spindles. We conclude that nonsynaptic GABA-ARs are recruited in a phasic manner specifically during burst firing of nRT cells and provide sufficient GABA-AR activation to control major thalamocortical oscillations.
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