期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 21, 页码 7216-7237出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4463-13.2014
关键词
Drosophila; information theory; phototransduction; sampling; stochasticity; vision
资金
- State Key Laboratory of Cognitive Neuroscience and Learning
- Natural Science Foundation of China [30810103906]
- Jane and Aatos Erkko Foundation
- Leverhulme Trust [RPG-2012-567]
- Biotechnology and Biological Sciences Research Council [BB/F012071/1, BB/D001900/1, BB/H013849/1]
- BBSRC [BB/D001900/1, BB/F012071/1, BB/H013849/1] Funding Source: UKRI
- EPSRC [EP/I017909/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H013849/1, BB/D001900/1, BB/F012071/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I017909/1] Funding Source: researchfish
Sensory neurons integrate information about the world, adapting their sampling to its changes. However, little is understood mechanistically how this primary encoding process, which ultimately limits perception, depends upon stimulus statistics. Here, we analyze this open question systematically by using intracellular recordings from fly (Drosophila melanogaster and Coenosia attenuata) photoreceptors and corresponding stochastic simulations from biophysically realistic photoreceptor models. Recordings show that photoreceptors can sample more information from naturalistic light intensity time series (NS) than from Gaussian white-noise (GWN), shuffled-NS or Gaussian-1/f stimuli; integrating larger responses with higher signal-to-noise ratio and encoding efficiency to large bursty contrast changes. Simulations reveal how a photoreceptor's information capture depends critically upon the stochastic refractoriness of its 30,000 sampling units (microvilli). In daylight, refractoriness sacrifices sensitivity to enhance intensity changes in neural image representations, with more and faster microvilli improving encoding. But for GWN and other stimuli, which lack longer dark contrasts of real-world intensity changes that reduce microvilli refractoriness, these performance gains are submaximal and energetically costly. These results provide mechanistic reasons why information sampling is more efficient for natural/naturalistic stimulation and novel insight into the operation, design, and evolution of signaling and code in sensory neurons.
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