期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 48, 页码 16103-16116出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2751-14.2014
关键词
cerebellum; corollary discharge; electric fish; proprioception; synaptic plasticity
资金
- National Science Foundation [1025849]
- National Institutes of Health (NIH) [NS075023]
- Alfred P. Sloan Foundation
- McKnight Endowment Fund
- National Research Service Award (NIH) [F31NS076334]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS075023, F31NS076334] Funding Source: NIH RePORTER
Animals must distinguish behaviorally relevant patterns of sensory stimulation from those that are attributable to their own movements. In principle, this distinction could be made based on internal signals related to motor commands, known as corollary discharge (CD), sensory feedback, or some combination of both. Here we use an advantageous model system-the electrosensory lobe (ELL) of weakly electric mormyrid fish-to directly examine how CD and proprioceptive feedback signals are transformed into negative images of the predictable electrosensory consequences of the fish's motor commands and/or movements. In vivo recordings from ELL neurons and theoretical modeling suggest that negative images are formed via anti-Hebbian plasticity acting on random, nonlinear mixtures of CD and proprioception. In support of this, we find that CD and proprioception are randomly mixed in spinal mossy fibers and that properties of granule cells are consistent with a nonlinear recoding of these signals. The mechanistic account provided here may be relevant to understanding how internal models of movement consequences are implemented in other systems in which similar components (e.g., mixed sensory and motor signals and synaptic plasticity) are found.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据