期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 6, 页码 2314-2320出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2202-13.2014
关键词
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资金
- Office of Naval Research Multidisciplinary University Research Initiative grant [ONR MURI N00014-10-1-0936]
- National Institutes of Health Silvio O. Conte Center for Neuroscience Research Grant [NIH P50 MH094263]
- NIH National Center for Research Resources Shared Instrumentation Grant Program [NIH P41RR14075]
Spatial navigation is a fundamental part of daily life. Humans differ in their individual abilities to flexibly navigate their world, and a critical question is how this variability relates to differences in underlying brain structure. Our experiment examined individual differences in the ability to flexibly navigate routes that overlap with, and must be distinguished from, previously learned trajectories. We related differences in flexible navigation performance to differences in brain morphology in healthy young adults using voxel-based morphometry. Our findings provide novel evidence that individual differences in gray matter volume in the hippocampus and dorsolateral prefrontal cortex correlate with our ability rapidly to learn and flexibly navigate routes through our world.
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