期刊
JOURNAL OF NEUROSCIENCE
卷 34, 期 34, 页码 11439-11451出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1355-14.2014
关键词
A delta-fibers; C-fibers; evoked potentials; first pain; nociception; second pain
资金
- National Natural Science Foundation of China [31200856]
- Natural Science Foundation Project of Chongqing Science and Technology Commission (CQ CSTC)
- Fundamental Research Funds for the Central Universities [SWU1409105]
- Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
- IASP Developed-Developing Countries Collaborative Research Grant
Intense radiant heat pulses concomitantly activate A delta-and C-fiber skin nociceptors, and elicit a typical double sensation: an initial A delta-related pricking pain is followed by a C-related prolonged burning sensation. It has been repeatedly reported that C-fiber laser-evoked potentials (C-LEPs) become detectable only when the concomitant activation of A delta-fibers is avoided or reduced. Given that the saliency of the eliciting stimulus is a major determinant of LEPs, one explanation for these observations is that the saliency of the C-input is smaller than that of the preceding A delta-input. However, even if the saliency of the C-input is reduced because of the preceding A delta-input, a C-LEP should still be visible even when preceded by an A delta-LEP response. Here we tested this hypothesis by applying advanced signal processing techniques (peak alignment and time-frequency decomposition) to electroencephalographic data collected in two experiments conducted in 34 and 96 healthy participants. We show that, when using optimal stimulus parameters (delivering >80 stimuli within a small skin territory), C-LEPs can be reliably detected in most participants. Importantly, C-LEPs are observed even when preceded by A delta-LEPs, both in average waveforms and single trials. By providing quantitative information about several response properties of C-LEPs (latency jitter, stimulus-response and perception-response functions, dependency on stimulus repetitions and stimulated area), these results define optimal parameters to record C-LEPs simply and reliably. These findings have important clinical implications for assessing small-fiber function in neuropathies and neuropathic pain.
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