期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 9, 页码 3834-3843出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3689-12.2013
关键词
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资金
- National Institutes of Health [K01MH091449, R01MH086867, R21MH085205, DP1 NS082121, R01DA030304]
- Japan Society for the Promotion of Science
- National Science Foundation Graduate Research Fellowship
- Sir Henry Wellcome Postdoctoral Fellowship from the Wellcome Trust
- Charles and Ann Sanders MGH Research Scholar award
- Grants-in-Aid for Scientific Research [24657052] Funding Source: KAKEN
Nonvisual photosensation enables animals to sense light without sight. However, the cellular and molecular mechanisms of nonvisual photobehaviors are poorly understood, especially in vertebrate animals. Here, we describe the photomotor response (PMR), a robust and reproducible series of motor behaviors in zebrafish that is elicited by visual wavelengths of light but does not require the eyes, pineal gland, or other canonical deep-brain photoreceptive organs. Unlike the relatively slow effects of canonical nonvisual pathways, motor circuits are strongly and quickly (seconds) recruited during the PMR behavior. We find that the hindbrain is both necessary and sufficient to drive these behaviors. Using in vivo calcium imaging, we identify a discrete set of neurons within the hindbrain whose responses to light mirror the PMR behavior. Pharmacological inhibition of the visual cycle blocks PMR behaviors, suggesting that opsin-based photoreceptors control this behavior. These data represent the first known light-sensing circuit in the vertebrate hindbrain.
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