期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 16, 页码 7057-7065出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.6267-11.2013
关键词
-
资金
- Wellcome Trust
- Medical Research Council
- Alzheimer's Research Trust (United Kingdom)
- National Institute for Health Research Cambridge Biomedical Research Centre
- Internationale Stiftung fur Forschung in Paraplegie
- European Union [223326, 223524, IEF 254801]
- European Union (European Research Council project ECMneuro)
- Acorda Therapeutics
- Alzheimers Research UK [ART-PG2011-20] Funding Source: researchfish
- Medical Research Council [MC_G1000734, G1000183B, G0001354B, G0001354] Funding Source: researchfish
- MRC [MC_G1000734] Funding Source: UKRI
Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control of brain plasticity and the closure of critical periods. Expression of the link protein Crtl1/Hapln1 in neurons has recently been identified as the key event triggering the formation of PNNs. Here we show that the genetic attenuation of PNNs in adult brain Crtl1 knock-out mice enhances long-term object recognition memory and facilitates long-term depression in the perirhinal cortex, a neural correlate of object recognition memory. Identical prolongation of memory follows localized digestion of PNNs with chondroitinase ABC, an enzyme that degrades the chondroitin sulfate proteoglycan components of PNNs. The memory-enhancing effect of chondroitinase ABC treatment attenuated over time, suggesting that the regeneration of PNNs gradually restored control plasticity levels. Our findings indicate that PNNs regulate both memory and experience-driven synaptic plasticity in adulthood.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据