期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 36, 页码 14591-14600出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5239-12.2013
关键词
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资金
- COST Action, Polish Ministry of Science and Higher Education [BM0901]
- TEAM project from the Foundation for Polish Science
- Foundation for Polish Science through its HOMING program
Learning how to avoid danger and pursue reward depends on negative emotions motivating aversive learning and positive emotions motivating appetitive learning. The amygdala is a key component of the brain emotional system; however, an understanding of how various emotions are differentially processed in the amygdala has yet to be achieved. We report that matrix metalloproteinase-9 (MMP-9, extracellularly operating enzyme) in the central nucleus of the amygdala (CeA) is crucial for appetitive, but not for aversive, learning in mice. The knock-out of MMP-9 impairs appetitively motivated conditioning, but not an aversive one. MMP-9 is present at the excitatory synapses in the CeA with its activity greatly enhanced after the appetitive training. Finally, blocking extracellular MMP-9 activity with its inhibitor TIMP-1 provides evidence that local MMP-9 activity in the CeA is crucial for the appetitive, but not for aversive, learning.
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