期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 15, 页码 6245-6256出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3672-12.2013
关键词
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资金
- NIH/NIA [5R00AG029726-03, 5R00AG029726-04, 3R00AG029726-04S1, (1R21AG033394-01]
- NIH/NINDS [1R01NS076794-01]
- Alzheimer's Association [IIRG-05-14993]
- NIMH
- Alzheimer's Association Zenith Fellows Award [ZEN-10-174633]
- Ellison Medical Foundation/American Federation for Aging Research Mid-Career Award in Aging Research [M11472]
- NIH/NIA T32 training grant [AG000096]
Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The amyloid cascade hypothesis posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia (Hardy and Allsop, 1991). Yet, faithful recapitulation of all AD features in widely used transgenic (Tg) mice engineered to overproduce A beta peptides has been elusive. We have developed a Tg rat model (line TgF344-AD) expressing mutant human amyloid precursor protein (APP(sw)) and presenilin 1 (PS1 Delta E9) genes, each independent causes of early-onset familial AD. TgF344-AD rats manifest age-dependent cerebral amyloidosis that precedes tauopathy, gliosis, apoptotic loss of neurons in the cerebral cortex and hippocampus, and cognitive disturbance. These results demonstrate progressive neurodegeneration of the Alzheimer type in these animals. The TgF344-AD rat fills a critical need for a next-generation animal model to enable basic and translational AD research.
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