期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 35, 页码 13978-U384出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2383-13.2013
关键词
-
资金
- National Institutes of Health (National Institute of Mental Health) [MH087581, MH0754047, MH089800]
- National Institutes of Health (National Research Service Award) [T32MH014654, F31MH097386]
- International Mental Health Research Organization
- National Alliance for Research in Schizophrenia and Affective Disorders
- National Institute on Drug Abuse [DA18678, DA22339]
Serotonin (5-HT) modulates neural responses to socioaffective cues and can bias approach or avoidance behavioral decisions, yet the cellular mechanisms underlying its contribution to the regulation of social experiences remain poorly understood. We hypothesized that GABAergic neurons in the dorsal raphe nucleus (DRN) may participate in socioaffective regulation by controlling serotonergic tone during social interaction. We tested this hypothesis using whole-cell recording techniques in genetically identified DRN GABA and 5-HT neurons in mice exposed to social defeat, a model that induces long-lasting avoidance behaviors in a subset of mice responsive to serotonergic antidepressants. Our results revealed that social defeat engaged DRN GABA neurons and drove GABAergic sensitization that strengthened inhibition of 5-HT neurons in mice that were susceptible, but not resilient to social defeat. Furthermore, optogenetic silencing of DRN GABA neurons disinhibited neighboring 5-HT neurons and prevented the acquisition of social avoidance in mice exposed to a social threat, but did not affect a previously acquired avoidance phenotype. We provide the first characterization of GABA neurons in the DRN that monosynaptically inhibit 5-HT neurons and reveal their key role in neuroplastic processes underlying the development of social avoidance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据