期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 17, 页码 7194-7205出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4967-12.2013
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资金
- National Eye Institute [R01EY021271]
- Sanofi-Aventis
- Salk Institute for Biological Studies
- Joseph Alexander Foundation
- National Science Foundation [PHY-0750525]
- National Institutes of Health [5R21EB004410]
- McKnight Foundation
- Engineering and Physical Sciences Research Council (EPSRC) [EP/E039731/1]
- Royal Society of Edinburgh
- Research Councils UK
- EPSRC [GR/R89189/01]
- Polish Ministry of Science and Higher Education
- Engineering and Physical Sciences Research Council [EP/G042446/1] Funding Source: researchfish
- EPSRC [EP/G042446/1] Funding Source: UKRI
Electrical stimulation of retinal neurons with an advanced retinal prosthesis may eventually provide high-resolution artificial vision to the blind. However, the success of future prostheses depends on the ability to activate the major parallel visual pathways of the human visual system. Electrical stimulation of the five numerically dominant retinal ganglion cell types was investigated by simultaneous stimulation and recording in isolated peripheral primate (Macaca sp.) retina using multi-electrode arrays. ON and OFF midget, ON and OFF parasol, and small bistratified ganglion cells could all be activated directly to fire a single spike with submillisecond latency using brief pulses of current within established safety limits. Thresholds for electrical stimulation were similar in all five cell types. In many cases, a single cell could be specifically activated without activating neighboring cells of the same type or other types. These findings support the feasibility of direct electrical stimulation of the major visual pathways at or near their native spatial and temporal resolution.
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