期刊
JOURNAL OF NEUROSCIENCE
卷 33, 期 13, 页码 5655-5667出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2973-12.2013
关键词
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资金
- National Institutes of Health [NS036350, NS050243, NS052290, NS059622]
- Indiana Spinal Cord and Brain Injury Research Fund (ISCBIRF)
- Mari Hulman George Endowments
Descending propriospinal neurons (DPSN) are known to establish functional relays for supraspinal signals, and they display a greater growth response after injury than do the long projecting axons. However, their regenerative response is still deficient due to their failure to depart from growth supportive cellular transplants back into the host spinal cord, which contains numerous impediments to axon growth. Here we report the construction of a continuous growth-promoting pathway in adult rats, formed by grafted Schwann cells overexpressing glial cell line-derived neurotrophic factor (GDNF). We demonstrate that such a growth-promoting pathway, extending from the axonal cut ends to the site of innervation in the distal spinal cord, promoted regeneration of DPSN axons through and beyond the lesion gap of a spinal cord hemisection. Within the distal host spinal cord, regenerated DPSN axons formed synapses with host neurons leading to the restoration of action potentials and partial recovery of function.
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